Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

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2-Chloro-3-amino-4-picoline (CAPIC) is taotao gk110 go kart parts a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients.A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methylnicotinonitrile, that terminates in a dead-end crystallization is described.The route uses inexpensive, acyclic commodity-based raw materials and has the potential to enable lower plastic molcajete bowls cost production of nevirapine as well as other value added structures that contain complex pyridines.The route terminates in a batch crystallization yielding high purity CAPIC.This outcome is expected to facilitate regulatory implementation of the overall process.